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發(fā)布時間：2018/12/21
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Dianova公司為德國的病理免疫組化產(chǎn)品供應(yīng)商，具備先進(jìn)的抗體制備工藝及嚴(yán)格的質(zhì)控系統(tǒng)，產(chǎn)品在上享有良好的聲譽(yù)。
Dianova DIA-AX1說明書
Art.-Nr.
DIA-AX1
特異性
ATRX
物種反應(yīng)性
人的
寄主物種
老鼠
同型
的IgG1 / K
克隆
AX1
克隆性（單克隆/多克?。?/span>
單克隆
應(yīng)用
免疫組化（石蠟包埋切片）
免疫組化（IHC）
共軛
非結(jié)合
稀釋
組織 - /細(xì)胞化學(xué)1：100-1：200
格式
純化的凍干抗體（來自培養(yǎng)上清液）
產(chǎn)品系列/主題
腫瘤標(biāo)志物/生物學(xué)
神經(jīng)生物學(xué)
免疫組織化學(xué)
有可能的使用
僅供研究使用
溫度 - 儲存
2-8℃
搜索代碼
FFPE
石蠟
DIAAX1
制造商/品牌
dianova
標(biāo)準(zhǔn)福爾馬林固定石蠟包埋膠質(zhì)瘤切片中人ATRX的免疫組織化學(xué)。
A：抗ATRX抗體克隆AX1在1p / 19q共同缺失的神經(jīng)膠質(zhì)瘤中的強(qiáng)核反應(yīng)。
B：通過抗ATRX免疫組織化學(xué)記錄的具有完整染色體1p / 19q的神經(jīng)膠質(zhì)瘤中核ATRX蛋白表達(dá)的喪失。
（A）1p / 19q的ATRX染色缺失膠質(zhì)瘤
B）神經(jīng)膠質(zhì)瘤中ATRX丟失，完整1p / 19q
（圖片由德國漢堡UKE神經(jīng)病理學(xué)系Marcus Glatzel教授提供）
ATRX（dianova clone AX1）和IDH1R132H（dianova clone H09）的組合免疫組織化學(xué)
取代了分子檢測。
用于診斷星形細(xì)胞瘤和少突神經(jīng)膠質(zhì)瘤的常規(guī)實用方法開始于針對ATRX和IDH1 R132H表達(dá)的執(zhí)行IHC。用ATRX和IDH1 R132H的初始IHC逐步分析分子參數(shù)，然后進(jìn)行1p / 19q分析，然后通過IDH測序，顯著減少了明確診斷所需的分子檢測次數(shù)（Reuss等，2015）。
背景
ATRX突變，IDH1突變和染色體1p / 19q共缺失是彌漫性膠質(zhì)瘤亞型診斷的關(guān)鍵分子因素。膠質(zhì)瘤中的ATRX突變導(dǎo)致核ATRX表達(dá)的喪失，其可通過IHC分析診斷。ATRX表達(dá)的喪失接近于與IDH1突變腫瘤中的1p / 19q共缺失相互排斥。因此，可以進(jìn)行ATRX免疫組織化學(xué)以通過FISH技術(shù)取代1p / 19q狀態(tài)的費(fèi)力分析。
參考
Dianova2019年產(chǎn)品價格表
貨號 | 品名 | 規(guī)格 | 價格 | 品牌 |
DIA-100 | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) | 200µg | 4680 | dianova |
DIA-100-M | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) | 20µg | 0 | dianova |
DIA-120 | Anti-Fibroblasten (CD90) (Hu) from Mouse (Clone: AS02) -FITC | 100test | 5360 | dianova |
DIA-530-P05 | Anti-p53 (Hu) from Mouse (Clone: CC53) | 0.5ml | 4780 | dianova |
DIA-530-M | Anti-p53 (Hu) from Mouse (Clone: CC53) | 0.1ml | 0 | dianova |
DIA-670-P05 | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) CE-IVD | 0.5ml | 4780 | dianova |
DIA-670-P1 | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) CE-IVD | 1ml | 6500 | dianova |
DIA-670-M | Anti-Ki-67/MIB1 (Hu) from Mouse (Clone: Ki-67P) CE-IVD | 0.1ml | 0 | dianova |
DIA-700-P05 | Anti-GFAP (Hu) from Mouse (Clone: IF3) CE-IVD | 0.5ml | 4780 | dianova |
DIA-700-M | Anti-GFAP (Hu) from Mouse (Clone: IF3) CE-IVD | 0.5ml | 0 | dianova |
DIA-AX1 | Anti-ATRX (Hu) from Mouse (Clone: AX1) | 0.5ml | 6760 | dianova |
DIA-CAL-100 | Anti-CALRETICULIN mutation (Hu) from Mouse (Clone CAL2) | 0.1ml | 5960 | dianova |
DIA-CAL-250 | Anti-CALRETICULIN mutation (Hu) from Mouse (Clone CAL2) | 0.25ml | 13960 | dianova |
DIA-H09 | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) CE-IVD | 0.5ml | 9640 | dianova |
DIA-H09-M | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09) CE-IVD | 0.1ml | 2840 | dianova |
DIA-H09-L | Anti-IDH1 R132H (Hu) from Mouse (Clone: H09), prediluted, ready-to-use | 8ml | 9640 | dianova |
DIA-W09 | Anti-IDH1 (Hu) from Rat (Clone: W09) | 0.5ml | 4960 | dianova |
DIA-TG1 | Anti-TIGIT (Hu) from Mouse (Clone TG1) | 0.5ml | 20400 | dianova |
DIA-TG1-M | Anti-TIGIT (Hu) from Mouse (Clone TG1) | 0.1ml | 5720 | dianova |
DIA-TC8 | Anti-CD8 (Hu) from Mouse (Clone TC8 ) | 0.5ml | 9200 | dianova |
DIA-P16-OD | Anti-P16 (Hu) from Mouse (Clone JAP16) | 0.1ml | 7360 | dianova |
DIA-303 | Anti-CD3 (Ms, FFPE) from Rat (Clone: HH3E) | 0.5ml | 6900 | dianova |
DIA-310 | Anti-CD31 (Ms, FFPE) from Rat (Clone: SZ31) | 0.5ml | 8040 | dianova |
DIA-404 | Anti-CD4 (Ms, FFPE) from Rat (Clone GHH8) | 0.2ml | 6900 | dianova |
DIA-808 | Anti-CD8a (Ms, FFPE) from Rat (Clone GHH8) | 0.2ml | 6900 | dianova |
DIA-60 | Anti-FasL, soluble (Hu) from Mouse (Clone: 94) | 1ml | 4760 | dianova |
DIA-900-100 | Anti-HIS-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone: 13/45/31) | 100µg | 2960 | dianova |
DIA-900-200 | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone: 13/45/31) | 200µg | 5160 | dianova |
DIA-900-FITC | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) -FITC | 1ml | 5960 | dianova |
DIA-900-BIOT | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) -Biotin | 100µg | 3960 | dianova |
DIA-910-200-ABF | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) Acid/BSA-free | 200µg | 4960 | dianova |
DIA.910-1MG-ABF | Anti-HIS Epitope-Tag (affinity 3x 10‐10M (Biacore™) from Mouse (Clone:13/45/31) Acid/BSA-free | 1mg | 19840 | dianova |
SCR-028841 | IS Adhesion Slides | 50pcs. | 1620 | dianova |
SCR-028855 | IS Adhesion Slides | 5pcs. | 詢價 | dianova |
SCR-028842 | IS Adhesion Slides | 100pcs. | 2440 | dianova |
SCR-038447 | Immunoselect Antifading Mounting Medium | 15ml | 960 | dianova |
SCR-038587 | Immunoselect Antifading Mounting Medium | 1ml | 詢價 | dianova |
SCR-038448 | Immunoselect Antifading Mounting Medium DAPI | 15ml | 1180 | dianova |
SCR-038588 | Immunoselect Antifading Mounting Medium DAPI | 1ml | 詢價 | dianova |
SCR-038449 | Immunoselect Antifading Mounting Medium PI | 15ml | 1180 | dianova |
SCR-072967 | Immunoselect Mounting Medium without hardener | 15ml | 960 | dianova |
SCR-093035 | Immunoselect Antifading Mounting Medium DAPI without hardener | 15ml | 1180 | dianova |
SCR-093036 | Immunoselect Antifading Mounting Medium PI without hardener | 15ml | 1180 | dianova |
DIA-0302-I | p53-auto antibody ELISA-Kit (Human) CE-IVD | 96test | 10960 | dianova |
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